Folinic acid, also known as 5-formyltetrahydrofolate, is a form of vitamin B9 that has been found to be beneficial in treating autism spectrum disorders. Studies have shown that children with autism have a deficiency in folinic acid and other forms of vitamin B9, which can lead to a number of neurological and behavioral symptoms.
The exact mechanism by which folinic acid is beneficial to those with autism is not entirely understood. However, some studies suggest that folinic acid may help to improve communication, social interactions, and daily living skills in children with autism.
One theory is that folinic acid may help to improve the function of the nervous system by reducing levels of homocysteine, an amino acid that has been linked to neurological disorders. Studies have found that individuals with autism have higher levels of homocysteine in their blood, which may contribute to the neurological and behavioral symptoms of autism. By reducing homocysteine levels through folinic acid supplementation, the nervous system may be able to function more effectively, which can help to improve communication, social interaction, and other autistic behaviors.
Another theory is that folinic acid may help to improve the function of the methylation cycle. The methylation cycle is a process that helps to regulate the expression of genes that are important for the development of the nervous system. Studies have found that individuals with autism have abnormalities in the methylation cycle, which may contribute to the neurological and behavioral symptoms of autism. By supplementing with folinic acid, it could help to improve the function of the methylation cycle and potentially lead to the improvement of autistic behavior.
It's worth noting that although studies have shown a correlation between folinic acid supplementation and improvement of autistic symptoms, more research is needed to fully understand the mechanisms behind the positive effects of folinic acid on autism.
Overall, it is suggested that folinic acid supplements can be an effective treatment for autism spectrum disorders. However, it is important to note that more research is needed to fully understand the mechanisms behind the positive effects of folinic acid on autism. Additionally, it is also important to consult with a qualified healthcare professional before starting any supplement regimen as there may be unwanted interactions with other medications or health conditions.
References:
1. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794882/
2. Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status: https://www.hindawi.com/journals/aurt/2013/609705/
3. A clinical trial at Phoenix Children's shows promising results for a treatment to improve communication skills in children with autism: https://phoenixchildrensfoundation.org/moments/bold-ideas/pioneering-new-treatments-for-autism/
4. Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials: https://www.frontiersin.org/articles/10.3389/fnins.2018.00019/full